Acute MDMA Exposure Causes Reference Memory Impairments in the Radial Arm Maze with Rats

Chlordiazepoxide specifically impairs nonspatial reference memory in the cued radial arm maze in rats.

Anxiolytic benzodiazepines, at low doses, reportedly impair the radial arm maze with nonspatial visual/tactile but not spatial cues. We replicated the former result controlling for changes in drug state and cue effectiveness. Rats learned an eight-arm radial maze with reward in only four arms. The reward varied in spatial position from trial to trial but was always cued by a piece of sandpaper ...

Spatial memory impairments in amnestic mild cognitive impairment in a virtual radial arm maze

OBJECTIVE This study aims to apply the virtual radial arm maze (VRAM) task to find spatial working memory and reference memory impairments in patients of amnestic mild cognitive impairment (aMCI) and Alzheimer's disease (AD). Spatial memory functions between aMCI converters and nonconverters are also compared using VRAM results. METHODS We assessed the spatial memory in 20 normal controls, 20...

Spatial memory in pigeons on a four-arm radial maze.

Within-Trial Dynamics of Radial Arm Maze Performance in Rats

The behavior of rats white solving a 12-arm radial maze was investigated using measures of response bias, choice latencies, and behavioral organization. Response bias decreased as a function of choice number, while the amount of time spent on the center platform between choices increased substantially during the last few choices. This increase in time between choices was largely accounted for b...

Nigella sativa Oil Enhances the Spatial Working Memory Performance of Rats on a Radial Arm Maze

Nigella sativa, an established historical and religion-based remedy for a wide range of health problems, is a herbal medicine known to have antioxidant and neuroprotective effects. This present study investigated the effect of Nigella sativa oil (NSO) administration on the spatial memory performance (SMP) of male adult rats using eight-arm radial arm maze (RAM). Twelve Sprague Dawley rats (7-9 ...